In 1964, at the Weizmann Institute of Science in Rehovot, Israel, Dr. Raphael Mechoulam – along with his colleagues, Dr. Yehiel Gaoni and Dr. Haviv Edery – succeeded in the very first isolation and elucidation of the active constituent of cannabis, D9-tetrahydrocannabinol, also known as THC. The discovery of the THC compound – now almost 50 years ago – started a revolution in thinking about cannabis that carries on to this day.